What 10 Studies Say About Colon Cancer

Colon Cancer Awareness

Colon cancer is also known as colorectal cancer, and it usually develops in the colon. A colon is also referred to as the large intestine, which is responsible for absorbing different minerals from the food. It also helps to remove any waste product that is left after food digestion. Small clusters of cells are first developed in the large intestine, and these clusters become cancerous later on to become colon cancer.

Many studies have helped to uncover the unknown facts about colon cancer. Some studies have also suggested different treatments, medications, and preventions related to colon cancer, helping many people against colorectal cancer.

Today we're going to talk about the 10 most popular studies about colon cancer to help you gain significant knowledge about colorectal cancer.

10 most popular studies about colon cancer:

In this section, we will talk about the 10 most popular studies related to colon cancer.

1.      Ethnicity plays an important role in colon cancer.

A research was conducted by NCI and the National Institute of Environmental Health Sciences (NEIH), which showed that people under 50 are more likely to get colon cancer than young adults. This research also found out that since the 1990s, colon cancer has seen to be doubled in adults older than 50 years or more of age.

Moreover, this research also uncovered the hidden fact that younger adults of ages between 20 – 35 had only a 1 -2% chance of getting colorectal cancer. This study showed that colon cancer is also dependent on ethnicity. According to this research, some of the ethnicities that were at the highest risk for developing colon cancer were:

  • African Americans
  • American Indians
  • People having white ethnicity.
  • People having an Alaskan background.

Overall, it was also observed that people with African American backgrounds were at the highest amount of risk of developing colon cancer even under the age of 50.

Gender

It was observed in the same study that the deadliest cancer in men was colorectal cancer or colon cancer, and in women, the deadliest cancer was breast cancer.

Country

The same study concluded that colon cancer is a leading cause of death in the United States of America. Every year 18,000-20,000 people in America are diagnosed with colon cancer, out of which some are mutated to form a more serious form of colon cancer.

2.      Diet is another factor in promoting colon cancer.

A study was conducted by the National Institute of Environmental Health (NIEH) to find out the exact cause which promoted the growth of colon cancer. The results of this study were astonishing as scientists found that people with no fiber in their diet and people who had meat and processed foods were more likely to be affected by this cancer.

Additionally, this study proved that people with specific unhygienic lifestyles and habits were more at risk of developing colorectal cancer. These factors were:

  • Smoking
  • Obesity, and
  • Lack of any physical activity

3.      Environmental Factors

Ethnicity plays an important role in colon cancer - Sappy Inspo Tees

A research was conducted by the National Toxicology Program, which helped to uncover the fact that colon cancer depends mainly on different environmental factors. This study found out that certain chemicals like endocrine and obesogens enter our bloodstream and then disrupt the metabolism rate and function, which leads to obesity, which is one of the main factors in promoting the growth of colon cancer cells.

Scientists conducting this research, such as Barbara Cohn, added that people certain chemicals are present in our environment, which significantly alters the DNA and, as a result, abnormal growth of cells in the colon occurs.

Percentage Ratio

In the same research, it was concluded by Kimmie Ng that genes and in-born factors only play a minor role in developing and promoting the growth of colorectal cancer cells. This role, when calculated in percentage, is about 10 -20. He further added that most colon cancers, even the most serious ones, are mainly caused by harsh and toxic environmental factors.

4.      Survival Chance is linked to Tumor Location.

A study conducted by NCI in 2016 found out that the chance of surviving after the early treatment was dependent on the location of colon cancer. People who had colon cancer originated from the left side of their colon, also known as the distal colon, lived a year longer than people who had their colon cancer originated from the right side of their colon.

Therapies

Some particularly targeted therapies were introduced in this study that showed some of the most promising results in curing colon cancer. These were:

  • Erbitux
  • Avastin

Observation

It was observed in this study that Erbitux was more beneficial for the patients who had their colon cancer originated from their left side, and Avastin was more beneficial for the patients who had their colon cancer originated from the right side of their colon.

5.      Colon cancer can spread.

A study was conducted by NCI on July 22, 2019, which suggested that colon cancer can spread to other parts of the body from its original location where it was born. This study also showed that mutations in other body parts are also possible when colon cancer cells come in contact with those body parts. Some of the organs that this study mentioned were:

  • Liver
  • Lungs
  • Brain
  • Heart

This study also suggested that different organs in our body have different kinds of tumors developed when colon cancer cells come in contact with these organs.

  1. Encorafenib can help against colon cancer.

Research conducted by the Food and Drug Administration on May 8, 2020, found out that two specific drugs helped cure colorectal cancer. These drugs were:

  • Encorafenib
  • Cetuximab

Encorafenib is also known as Bravftovi, helped cure colon cancer patients. This study suggested that combining Encorafenib with Cetuximab halted the growth of colon cancer cells and also stopped them from affecting other parts of the body.

 BRAF Protein

This study also found that Encorafenib helped cure people having colon cancer with BRAF mutation, out of which the V600E mutation was the main one.

7.      Early detection of colon cancer can help people cure it.

 Early detection of colon cancer can help people cure it - Sappy Inspo Tees

The research was held by the National Cancer Institute on 17 June 2019, which included the most well-known cancer researcher Christina Curtis, who concluded that early screenings could be beneficial as one can know about their body and colon cancer.

She concluded that doctors could actually help people who if colorectal cancer or colon cancer is diagnosed at a very early stage.

Metastatic Tumor

In the same study, Nancy Boudreau found and concluded that people with metastatic colon cancer are harder to treat, as treatments and medications that particularly target metastatic tumors aren't available. This makes this form of colon cancer more challenging for the doctors and life-threatening to colon cancer patients.

8.      Lynch Syndrome

A study was conducted in 2017 which proved that people with Lynch syndrome had increased risk factors of colon cancer. This study was conducted by Steven Lipkin, who concluded that there's actually a vaccine to help counter the effects of Lynch syndrome, which affects colon cancer.

Genetic Testing

Steven Lipkin also concluded that genetic testing and frequent cancer-related screenings are helpful in detecting Lynch syndrome, which is vital to cure, especially if a person is diagnosed with colon cancer. He further added that aspirins in low doses that are specially made to prevent colon cancer and several surgeries helped the patients against Lynch syndrome, which directly affected colon cancer.

9.      Immunotherapy drugs are better than chemotherapy in curing colon cancer.

A study was conducted in 2016, which helped to prove that immunotherapy drugs are better than chemotherapy to cure colon cancer. The drugs that were found out to be helpful against colon cancer were:

  • Ipilimumab (Yervoy), and
  • Nivolumab (Opdivo)

DNA Mutations

These drugs were tested, and it was found that they both helped patients with colon cancer to repair their damaged DNA and high microsatellite instability. The patients who had these DNA mutations in their bloodstream were found to have the worst type of colon cancer.

10. TAS-102

A study was held in which 800 patients with colon cancer were brought together from different regions of the world. These patients were distributed in the ratio of 2:1 and were given an oral drug known as TAS-102.

Observation

It was observed that TAS-102 helped to counter the colon cancer cells in a way that was not affected by any other kinds of treatments, medicines, and therapies. Before getting the TAS-102 (oral drug), patients that were brought together were given chemotherapy which included the following drugs:

  • Fluoropyrimidine
  • Oxaliplatin
  • Irinotecan
  • Bevacizumab

Final Results

The patients who were given the dose of TAS-102 experienced fewer contrary events than the patients who were not given the TAS-102 oral drug. It was also found that patients who had received the TAS-102 drug had formed the capability to control the colon cancer disease in their immune system.

Conclusion

The above-mentioned are the 10 top-most studies about colon cancer. These studies have played a major role in expanding the knowledge related to colon cancer.

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